The University Of Illinois College Of Veterinary Medicine Center for One Health Illinois, The Zoo Animal Health Network, and the United States Department of Agriculture (USDA) Animal Care Emergency Programs are pleased to collaborate on ‘Flu at the Zoo‛! This is a tabletop exercise is designed to bring together zoos and aquariums in a tri-state region, with regulators and animal health partners to simulate the outbreak of avian influenza (AI) in zoological facilities. While Association of Zoos and Aquariums zoos and USDA have invested time and resources in preparing for AI, the opportunities to evaluate our training, preparedness and response is limited. The Flu at the Zoo team will bring together staff from zoos in Illinois, Indiana and Missouri for a one-day table top exercise to evaluate AZA institutional capacity to respond to an outbreak of avian influenza within a zoological facility. A goal of this exercise is to enhance communication across all participating agencies and increase facility and community preparedness; not only important for AI but for any infectious disease outbreak involving a zoo.